Reduced-intensity conditioning and HLA-matched haemopoietic stem-cell transplantation in patients with chronic granulomatous disease: a prospective multicentre study.
Identifieur interne : 003569 ( Main/Exploration ); précédent : 003568; suivant : 003570Reduced-intensity conditioning and HLA-matched haemopoietic stem-cell transplantation in patients with chronic granulomatous disease: a prospective multicentre study.
Auteurs : Tayfun Güngör [Suisse] ; Pierre Teira [Canada] ; Mary Slatter [Royaume-Uni] ; Georg Stussi [Suisse] ; Polina Stepensky [Israël] ; Despina Moshous [France] ; Clementien Vermont [Pays-Bas] ; Imran Ahmad [Canada] ; Peter J. Shaw [Australie] ; José Marcos Telles Da Cunha [Brésil] ; Paul G. Schlegel [Allemagne] ; Rachel Hough [Royaume-Uni] ; Anders Fasth [Suède] ; Karim Kentouche [Allemagne] ; Bernd Gruhn [Allemagne] ; Juliana F. Fernandes [Brésil] ; Silvy Lachance [Canada] ; Robbert Bredius [Pays-Bas] ; Igor B. Resnick [Israël] ; Bernd H. Belohradsky [Allemagne] ; Andrew Gennery [Royaume-Uni] ; Alain Fischer [France] ; H Bobby Gaspar [Royaume-Uni] ; Urs Schanz [Suisse] ; Reinhard Seger [Suisse] ; Katharina Rentsch [Suède] ; Paul Veys [Royaume-Uni] ; Elie Haddad [Canada] ; Michael H. Albert [Allemagne] ; Moustapha Hassan [Suède]Source :
- Lancet (London, England) [ 1474-547X ] ; 2014.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Anticorps monoclonaux humanisés (administration et posologie), Antigènes HLA, Association de médicaments, Busulfan (administration et posologie), Chimère obtenue par transplantation (physiologie), Conditionnement pour greffe (), Enfant, Enfant d'âge préscolaire, Granulomatose septique chronique (), Humains, Immunosuppresseurs (administration et posologie), Jeune adulte, Maladie du greffon contre l'hôte (), Nourrisson, Résultat thérapeutique, Survie du greffon (), Sérum antilymphocyte (administration et posologie), Transplantation de cellules souches hématopoïétiques (), Vidarabine (administration et posologie), Vidarabine (analogues et dérivés), Études prospectives.
- MESH :
- administration et posologie : Anticorps monoclonaux humanisés, Busulfan, Immunosuppresseurs, Sérum antilymphocyte, Vidarabine.
- analogues et dérivés : Vidarabine.
- physiologie : Chimère obtenue par transplantation.
- Adolescent, Adulte, Antigènes HLA, Association de médicaments, Conditionnement pour greffe, Enfant, Enfant d'âge préscolaire, Granulomatose septique chronique, Humains, Jeune adulte, Maladie du greffon contre l'hôte, Nourrisson, Résultat thérapeutique, Survie du greffon, Transplantation de cellules souches hématopoïétiques, Études prospectives.
English descriptors
- KwdEn :
- Adolescent, Adult, Antibodies, Monoclonal, Humanized (administration & dosage), Antilymphocyte Serum (administration & dosage), Busulfan (administration & dosage), Child, Child, Preschool, Drug Therapy, Combination, Graft Survival (drug effects), Graft vs Host Disease (prevention & control), Granulomatous Disease, Chronic (therapy), HLA Antigens, Hematopoietic Stem Cell Transplantation (methods), Humans, Immunosuppressive Agents (administration & dosage), Infant, Prospective Studies, Transplantation Chimera (physiology), Transplantation Conditioning (methods), Treatment Outcome, Vidarabine (administration & dosage), Vidarabine (analogs & derivatives), Young Adult.
- MESH :
- chemical , administration & dosage : Antibodies, Monoclonal, Humanized, Antilymphocyte Serum, Busulfan, Immunosuppressive Agents, Vidarabine.
- chemical , analogs & derivatives : Vidarabine.
- drug effects : Graft Survival.
- methods : Hematopoietic Stem Cell Transplantation, Transplantation Conditioning.
- physiology : Transplantation Chimera.
- prevention & control : Graft vs Host Disease.
- therapy : Granulomatous Disease, Chronic.
- Adolescent, Adult, Child, Child, Preschool, Drug Therapy, Combination, HLA Antigens, Humans, Infant, Prospective Studies, Treatment Outcome, Young Adult.
Abstract
In chronic granulomatous disease allogeneic haemopoietic stem-cell transplantation (HSCT) in adolescents and young adults and patients with high-risk disease is complicated by graft-failure, graft-versus-host disease (GVHD), and transplant-related mortality. We examined the effect of a reduced-intensity conditioning regimen designed to enhance myeloid engraftment and reduce organ toxicity in these patients.
DOI: 10.1016/S0140-6736(13)62069-3
PubMed: 24161820
Affiliations:
- Allemagne, Australie, Brésil, Canada, France, Israël, Pays-Bas, Royaume-Uni, Suisse, Suède
- Angleterre, Bavière, Canton de Zurich, District de Basse-Franconie, District de Haute-Bavière, Grand Londres, Hollande-Méridionale, Svealand, État de São Paulo, Île-de-France
- Leyde, Londres, Munich, Paris, Stockholm, São Paulo, Wurtzbourg, Zurich
- Université Paris-Descartes, Université de São Paulo
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Le document en format XML
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Electronic address: tayfun.guengoer@kispi.uzh.ch.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>University Children's Hospital, Division of Blood and Marrow Transplantation, Zurich</wicri:regionArea><wicri:noRegion>Zurich</wicri:noRegion></affiliation></author><author><name sortKey="Teira, Pierre" sort="Teira, Pierre" uniqKey="Teira P" first="Pierre" last="Teira">Pierre Teira</name><affiliation wicri:level="1"><nlm:affiliation>Centre de Recherche du CHU Sainte-Justine, Département de Pédiatrie, Université de Montréal, Montréal, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre de Recherche du CHU Sainte-Justine, Département de Pédiatrie, Université de Montréal, Montréal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Slatter, Mary" sort="Slatter, Mary" uniqKey="Slatter M" first="Mary" last="Slatter">Mary Slatter</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Stussi, Georg" sort="Stussi, Georg" uniqKey="Stussi G" first="Georg" last="Stussi">Georg Stussi</name><affiliation wicri:level="3"><nlm:affiliation>University Hospital, Division of Hematology and Blood and Marrow Transplantation, Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>University Hospital, Division of Hematology and Blood and Marrow Transplantation, Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Stepensky, Polina" sort="Stepensky, Polina" uniqKey="Stepensky P" first="Polina" last="Stepensky">Polina Stepensky</name><affiliation wicri:level="1"><nlm:affiliation>Hadassah Hebrew University Medical Center, Department of Blood and Marrow Transplantation, Jerusalem, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Hadassah Hebrew University Medical Center, Department of Blood and Marrow Transplantation, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Moshous, Despina" sort="Moshous, Despina" uniqKey="Moshous D" first="Despina" last="Moshous">Despina Moshous</name><affiliation wicri:level="4"><nlm:affiliation>AP-HP, Hôpital Necker Enfants Malades, Paediatric Immunology, Sorbonne Paris Cité, Université Paris Descartes, Imagine Institute, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Hôpital Necker Enfants Malades, Paediatric Immunology, Sorbonne Paris Cité, Université Paris Descartes, Imagine Institute, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Vermont, Clementien" sort="Vermont, Clementien" uniqKey="Vermont C" first="Clementien" last="Vermont">Clementien Vermont</name><affiliation wicri:level="3"><nlm:affiliation>Leiden University Medical Center, Department of Paediatrics, Leiden, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Leiden University Medical Center, Department of Paediatrics, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Ahmad, Imran" sort="Ahmad, Imran" uniqKey="Ahmad I" first="Imran" last="Ahmad">Imran Ahmad</name><affiliation wicri:level="1"><nlm:affiliation>Blood and Marrow Transplantation Program, Hôpital Maisonneuve-Rosemont, Université de Montréal, Montréal, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Blood and Marrow Transplantation Program, Hôpital Maisonneuve-Rosemont, Université de Montréal, Montréal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Shaw, Peter J" sort="Shaw, Peter J" uniqKey="Shaw P" first="Peter J" last="Shaw">Peter J. Shaw</name><affiliation wicri:level="1"><nlm:affiliation>Children's Hospital, Division of Blood and Marrow Transplantation, Westmead, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Children's Hospital, Division of Blood and Marrow Transplantation, Westmead, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Telles Da Cunha, Jose Marcos" sort="Telles Da Cunha, Jose Marcos" uniqKey="Telles Da Cunha J" first="José Marcos" last="Telles Da Cunha">José Marcos Telles Da Cunha</name><affiliation wicri:level="3"><nlm:affiliation>Hospital Albert Einstein, Haematology and Hematopoietic stem cell transplantation Unit, Sao Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Albert Einstein, Haematology and Hematopoietic stem cell transplantation Unit, Sao Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Schlegel, Paul G" sort="Schlegel, Paul G" uniqKey="Schlegel P" first="Paul G" last="Schlegel">Paul G. Schlegel</name><affiliation wicri:level="3"><nlm:affiliation>University Children's Hospital, Division of Blood and Marrow Transplantation, Würzburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Children's Hospital, Division of Blood and Marrow Transplantation, Würzburg</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Hough, Rachel" sort="Hough, Rachel" uniqKey="Hough R" first="Rachel" last="Hough">Rachel Hough</name><affiliation wicri:level="3"><nlm:affiliation>University College London Hospitals NHS Foundation Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University College London Hospitals NHS Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Fasth, Anders" sort="Fasth, Anders" uniqKey="Fasth A" first="Anders" last="Fasth">Anders Fasth</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, University of Gothenburg, Gothenburg, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Pediatrics, University of Gothenburg, Gothenburg</wicri:regionArea><wicri:noRegion>Gothenburg</wicri:noRegion></affiliation></author><author><name sortKey="Kentouche, Karim" sort="Kentouche, Karim" uniqKey="Kentouche K" first="Karim" last="Kentouche">Karim Kentouche</name><affiliation wicri:level="1"><nlm:affiliation>Department of Paediatrics, Jena University Hospital, Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Paediatrics, Jena University Hospital, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Gruhn, Bernd" sort="Gruhn, Bernd" uniqKey="Gruhn B" first="Bernd" last="Gruhn">Bernd Gruhn</name><affiliation wicri:level="1"><nlm:affiliation>Department of Paediatrics, Jena University Hospital, Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Paediatrics, Jena University Hospital, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Fernandes, Juliana F" sort="Fernandes, Juliana F" uniqKey="Fernandes J" first="Juliana F" last="Fernandes">Juliana F. Fernandes</name><affiliation wicri:level="4"><nlm:affiliation>Instituto da Criança, Universidade de São Paulo, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Instituto da Criança, Universidade de São Paulo, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region><settlement type="city">São Paulo</settlement></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Lachance, Silvy" sort="Lachance, Silvy" uniqKey="Lachance S" first="Silvy" last="Lachance">Silvy Lachance</name><affiliation wicri:level="1"><nlm:affiliation>Blood and Marrow Transplantation Program, Hôpital Maisonneuve-Rosemont, Université de Montréal, Montréal, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Blood and Marrow Transplantation Program, Hôpital Maisonneuve-Rosemont, Université de Montréal, Montréal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Bredius, Robbert" sort="Bredius, Robbert" uniqKey="Bredius R" first="Robbert" last="Bredius">Robbert Bredius</name><affiliation wicri:level="3"><nlm:affiliation>Leiden University Medical Center, Department of Paediatrics, Leiden, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Leiden University Medical Center, Department of Paediatrics, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Resnick, Igor B" sort="Resnick, Igor B" uniqKey="Resnick I" first="Igor B" last="Resnick">Igor B. Resnick</name><affiliation wicri:level="1"><nlm:affiliation>Hadassah Hebrew University Medical Center, Department of Blood and Marrow Transplantation, Jerusalem, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Hadassah Hebrew University Medical Center, Department of Blood and Marrow Transplantation, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Belohradsky, Bernd H" sort="Belohradsky, Bernd H" uniqKey="Belohradsky B" first="Bernd H" last="Belohradsky">Bernd H. Belohradsky</name><affiliation wicri:level="3"><nlm:affiliation>Dr von Hauner University Children's Hospital, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Dr von Hauner University Children's Hospital, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Gennery, Andrew" sort="Gennery, Andrew" uniqKey="Gennery A" first="Andrew" last="Gennery">Andrew Gennery</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Fischer, Alain" sort="Fischer, Alain" uniqKey="Fischer A" first="Alain" last="Fischer">Alain Fischer</name><affiliation wicri:level="4"><nlm:affiliation>AP-HP, Hôpital Necker Enfants Malades, Paediatric Immunology, Sorbonne Paris Cité, Université Paris Descartes, Imagine Institute, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Hôpital Necker Enfants Malades, Paediatric Immunology, Sorbonne Paris Cité, Université Paris Descartes, Imagine Institute, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Gaspar, H Bobby" sort="Gaspar, H Bobby" uniqKey="Gaspar H" first="H Bobby" last="Gaspar">H Bobby Gaspar</name><affiliation wicri:level="3"><nlm:affiliation>Great Ormond Street Children's Hospital, Division of Blood and Marrow Transplantation, London, UK; Molecular Immunology Unit; UCL Institute of Child Health, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Great Ormond Street Children's Hospital, Division of Blood and Marrow Transplantation, London, UK; Molecular Immunology Unit; UCL Institute of Child Health, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Schanz, Urs" sort="Schanz, Urs" uniqKey="Schanz U" first="Urs" last="Schanz">Urs Schanz</name><affiliation wicri:level="3"><nlm:affiliation>University Hospital, Division of Hematology and Blood and Marrow Transplantation, Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>University Hospital, Division of Hematology and Blood and Marrow Transplantation, Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Seger, Reinhard" sort="Seger, Reinhard" uniqKey="Seger R" first="Reinhard" last="Seger">Reinhard Seger</name><affiliation wicri:level="1"><nlm:affiliation>University Children's Hospital, Division of Blood and Marrow Transplantation, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>University Children's Hospital, Division of Blood and Marrow Transplantation, Zurich</wicri:regionArea><wicri:noRegion>Zurich</wicri:noRegion></affiliation></author><author><name sortKey="Rentsch, Katharina" sort="Rentsch, Katharina" uniqKey="Rentsch K" first="Katharina" last="Rentsch">Katharina Rentsch</name><affiliation wicri:level="1"><nlm:affiliation>University Hospital, Divison of Clinical Chemistry, KFC, Novum, Laboratory Medicine, Karolinska University Hospital-Huddinge Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>University Hospital, Divison of Clinical Chemistry, KFC, Novum, Laboratory Medicine, Karolinska University Hospital-Huddinge Stockholm</wicri:regionArea><wicri:noRegion>Karolinska University Hospital-Huddinge Stockholm</wicri:noRegion></affiliation></author><author><name sortKey="Veys, Paul" sort="Veys, Paul" uniqKey="Veys P" first="Paul" last="Veys">Paul Veys</name><affiliation wicri:level="3"><nlm:affiliation>Great Ormond Street Children's Hospital, Division of Blood and Marrow Transplantation, London, UK; Molecular Immunology Unit; UCL Institute of Child Health, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Great Ormond Street Children's Hospital, Division of Blood and Marrow Transplantation, London, UK; Molecular Immunology Unit; UCL Institute of Child Health, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Haddad, Elie" sort="Haddad, Elie" uniqKey="Haddad E" first="Elie" last="Haddad">Elie Haddad</name><affiliation wicri:level="1"><nlm:affiliation>Centre de Recherche du CHU Sainte-Justine, Département de Pédiatrie, Université de Montréal, Montréal, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre de Recherche du CHU Sainte-Justine, Département de Pédiatrie, Université de Montréal, Montréal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Albert, Michael H" sort="Albert, Michael H" uniqKey="Albert M" first="Michael H" last="Albert">Michael H. Albert</name><affiliation wicri:level="3"><nlm:affiliation>Dr von Hauner University Children's Hospital, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Dr von Hauner University Children's Hospital, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Hassan, Moustapha" sort="Hassan, Moustapha" uniqKey="Hassan M" first="Moustapha" last="Hassan">Moustapha Hassan</name><affiliation wicri:level="3"><nlm:affiliation>Division of Experimental Cancer Medicine, KFC, Novum, Laboratory Medicine, Karolinska University Hospital-Huddinge Stockholm, Sweden; Karolinska Institute, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Experimental Cancer Medicine, KFC, Novum, Laboratory Medicine, Karolinska University Hospital-Huddinge Stockholm, Sweden; Karolinska Institute, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24161820</idno><idno type="pmid">24161820</idno><idno type="doi">10.1016/S0140-6736(13)62069-3</idno><idno type="wicri:Area/PubMed/Corpus">003952</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003952</idno><idno type="wicri:Area/PubMed/Curation">003837</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003837</idno><idno type="wicri:Area/PubMed/Checkpoint">003837</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003837</idno><idno type="wicri:Area/Ncbi/Merge">001537</idno><idno type="wicri:Area/Ncbi/Curation">001537</idno><idno type="wicri:Area/Ncbi/Checkpoint">001537</idno><idno type="wicri:Area/Main/Merge">003586</idno><idno type="wicri:Area/Main/Curation">003569</idno><idno type="wicri:Area/Main/Exploration">003569</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Reduced-intensity conditioning and HLA-matched haemopoietic stem-cell transplantation in patients with chronic granulomatous disease: a prospective multicentre study.</title><author><name sortKey="Gungor, Tayfun" sort="Gungor, Tayfun" uniqKey="Gungor T" first="Tayfun" last="Güngör">Tayfun Güngör</name><affiliation wicri:level="1"><nlm:affiliation>University Children's Hospital, Division of Blood and Marrow Transplantation, Zurich, Switzerland. Electronic address: tayfun.guengoer@kispi.uzh.ch.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>University Children's Hospital, Division of Blood and Marrow Transplantation, Zurich</wicri:regionArea><wicri:noRegion>Zurich</wicri:noRegion></affiliation></author><author><name sortKey="Teira, Pierre" sort="Teira, Pierre" uniqKey="Teira P" first="Pierre" last="Teira">Pierre Teira</name><affiliation wicri:level="1"><nlm:affiliation>Centre de Recherche du CHU Sainte-Justine, Département de Pédiatrie, Université de Montréal, Montréal, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre de Recherche du CHU Sainte-Justine, Département de Pédiatrie, Université de Montréal, Montréal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Slatter, Mary" sort="Slatter, Mary" uniqKey="Slatter M" first="Mary" last="Slatter">Mary Slatter</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Stussi, Georg" sort="Stussi, Georg" uniqKey="Stussi G" first="Georg" last="Stussi">Georg Stussi</name><affiliation wicri:level="3"><nlm:affiliation>University Hospital, Division of Hematology and Blood and Marrow Transplantation, Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>University Hospital, Division of Hematology and Blood and Marrow Transplantation, Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Stepensky, Polina" sort="Stepensky, Polina" uniqKey="Stepensky P" first="Polina" last="Stepensky">Polina Stepensky</name><affiliation wicri:level="1"><nlm:affiliation>Hadassah Hebrew University Medical Center, Department of Blood and Marrow Transplantation, Jerusalem, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Hadassah Hebrew University Medical Center, Department of Blood and Marrow Transplantation, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Moshous, Despina" sort="Moshous, Despina" uniqKey="Moshous D" first="Despina" last="Moshous">Despina Moshous</name><affiliation wicri:level="4"><nlm:affiliation>AP-HP, Hôpital Necker Enfants Malades, Paediatric Immunology, Sorbonne Paris Cité, Université Paris Descartes, Imagine Institute, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Hôpital Necker Enfants Malades, Paediatric Immunology, Sorbonne Paris Cité, Université Paris Descartes, Imagine Institute, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Vermont, Clementien" sort="Vermont, Clementien" uniqKey="Vermont C" first="Clementien" last="Vermont">Clementien Vermont</name><affiliation wicri:level="3"><nlm:affiliation>Leiden University Medical Center, Department of Paediatrics, Leiden, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Leiden University Medical Center, Department of Paediatrics, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Ahmad, Imran" sort="Ahmad, Imran" uniqKey="Ahmad I" first="Imran" last="Ahmad">Imran Ahmad</name><affiliation wicri:level="1"><nlm:affiliation>Blood and Marrow Transplantation Program, Hôpital Maisonneuve-Rosemont, Université de Montréal, Montréal, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Blood and Marrow Transplantation Program, Hôpital Maisonneuve-Rosemont, Université de Montréal, Montréal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Shaw, Peter J" sort="Shaw, Peter J" uniqKey="Shaw P" first="Peter J" last="Shaw">Peter J. Shaw</name><affiliation wicri:level="1"><nlm:affiliation>Children's Hospital, Division of Blood and Marrow Transplantation, Westmead, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Children's Hospital, Division of Blood and Marrow Transplantation, Westmead, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Telles Da Cunha, Jose Marcos" sort="Telles Da Cunha, Jose Marcos" uniqKey="Telles Da Cunha J" first="José Marcos" last="Telles Da Cunha">José Marcos Telles Da Cunha</name><affiliation wicri:level="3"><nlm:affiliation>Hospital Albert Einstein, Haematology and Hematopoietic stem cell transplantation Unit, Sao Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Albert Einstein, Haematology and Hematopoietic stem cell transplantation Unit, Sao Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Schlegel, Paul G" sort="Schlegel, Paul G" uniqKey="Schlegel P" first="Paul G" last="Schlegel">Paul G. Schlegel</name><affiliation wicri:level="3"><nlm:affiliation>University Children's Hospital, Division of Blood and Marrow Transplantation, Würzburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Children's Hospital, Division of Blood and Marrow Transplantation, Würzburg</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Hough, Rachel" sort="Hough, Rachel" uniqKey="Hough R" first="Rachel" last="Hough">Rachel Hough</name><affiliation wicri:level="3"><nlm:affiliation>University College London Hospitals NHS Foundation Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University College London Hospitals NHS Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Fasth, Anders" sort="Fasth, Anders" uniqKey="Fasth A" first="Anders" last="Fasth">Anders Fasth</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, University of Gothenburg, Gothenburg, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Pediatrics, University of Gothenburg, Gothenburg</wicri:regionArea><wicri:noRegion>Gothenburg</wicri:noRegion></affiliation></author><author><name sortKey="Kentouche, Karim" sort="Kentouche, Karim" uniqKey="Kentouche K" first="Karim" last="Kentouche">Karim Kentouche</name><affiliation wicri:level="1"><nlm:affiliation>Department of Paediatrics, Jena University Hospital, Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Paediatrics, Jena University Hospital, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Gruhn, Bernd" sort="Gruhn, Bernd" uniqKey="Gruhn B" first="Bernd" last="Gruhn">Bernd Gruhn</name><affiliation wicri:level="1"><nlm:affiliation>Department of Paediatrics, Jena University Hospital, Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Paediatrics, Jena University Hospital, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Fernandes, Juliana F" sort="Fernandes, Juliana F" uniqKey="Fernandes J" first="Juliana F" last="Fernandes">Juliana F. Fernandes</name><affiliation wicri:level="4"><nlm:affiliation>Instituto da Criança, Universidade de São Paulo, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Instituto da Criança, Universidade de São Paulo, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region><settlement type="city">São Paulo</settlement></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Lachance, Silvy" sort="Lachance, Silvy" uniqKey="Lachance S" first="Silvy" last="Lachance">Silvy Lachance</name><affiliation wicri:level="1"><nlm:affiliation>Blood and Marrow Transplantation Program, Hôpital Maisonneuve-Rosemont, Université de Montréal, Montréal, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Blood and Marrow Transplantation Program, Hôpital Maisonneuve-Rosemont, Université de Montréal, Montréal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Bredius, Robbert" sort="Bredius, Robbert" uniqKey="Bredius R" first="Robbert" last="Bredius">Robbert Bredius</name><affiliation wicri:level="3"><nlm:affiliation>Leiden University Medical Center, Department of Paediatrics, Leiden, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Leiden University Medical Center, Department of Paediatrics, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Resnick, Igor B" sort="Resnick, Igor B" uniqKey="Resnick I" first="Igor B" last="Resnick">Igor B. Resnick</name><affiliation wicri:level="1"><nlm:affiliation>Hadassah Hebrew University Medical Center, Department of Blood and Marrow Transplantation, Jerusalem, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Hadassah Hebrew University Medical Center, Department of Blood and Marrow Transplantation, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Belohradsky, Bernd H" sort="Belohradsky, Bernd H" uniqKey="Belohradsky B" first="Bernd H" last="Belohradsky">Bernd H. Belohradsky</name><affiliation wicri:level="3"><nlm:affiliation>Dr von Hauner University Children's Hospital, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Dr von Hauner University Children's Hospital, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Gennery, Andrew" sort="Gennery, Andrew" uniqKey="Gennery A" first="Andrew" last="Gennery">Andrew Gennery</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Fischer, Alain" sort="Fischer, Alain" uniqKey="Fischer A" first="Alain" last="Fischer">Alain Fischer</name><affiliation wicri:level="4"><nlm:affiliation>AP-HP, Hôpital Necker Enfants Malades, Paediatric Immunology, Sorbonne Paris Cité, Université Paris Descartes, Imagine Institute, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Hôpital Necker Enfants Malades, Paediatric Immunology, Sorbonne Paris Cité, Université Paris Descartes, Imagine Institute, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Gaspar, H Bobby" sort="Gaspar, H Bobby" uniqKey="Gaspar H" first="H Bobby" last="Gaspar">H Bobby Gaspar</name><affiliation wicri:level="3"><nlm:affiliation>Great Ormond Street Children's Hospital, Division of Blood and Marrow Transplantation, London, UK; Molecular Immunology Unit; UCL Institute of Child Health, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Great Ormond Street Children's Hospital, Division of Blood and Marrow Transplantation, London, UK; Molecular Immunology Unit; UCL Institute of Child Health, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Schanz, Urs" sort="Schanz, Urs" uniqKey="Schanz U" first="Urs" last="Schanz">Urs Schanz</name><affiliation wicri:level="3"><nlm:affiliation>University Hospital, Division of Hematology and Blood and Marrow Transplantation, Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>University Hospital, Division of Hematology and Blood and Marrow Transplantation, Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Seger, Reinhard" sort="Seger, Reinhard" uniqKey="Seger R" first="Reinhard" last="Seger">Reinhard Seger</name><affiliation wicri:level="1"><nlm:affiliation>University Children's Hospital, Division of Blood and Marrow Transplantation, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>University Children's Hospital, Division of Blood and Marrow Transplantation, Zurich</wicri:regionArea><wicri:noRegion>Zurich</wicri:noRegion></affiliation></author><author><name sortKey="Rentsch, Katharina" sort="Rentsch, Katharina" uniqKey="Rentsch K" first="Katharina" last="Rentsch">Katharina Rentsch</name><affiliation wicri:level="1"><nlm:affiliation>University Hospital, Divison of Clinical Chemistry, KFC, Novum, Laboratory Medicine, Karolinska University Hospital-Huddinge Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>University Hospital, Divison of Clinical Chemistry, KFC, Novum, Laboratory Medicine, Karolinska University Hospital-Huddinge Stockholm</wicri:regionArea><wicri:noRegion>Karolinska University Hospital-Huddinge Stockholm</wicri:noRegion></affiliation></author><author><name sortKey="Veys, Paul" sort="Veys, Paul" uniqKey="Veys P" first="Paul" last="Veys">Paul Veys</name><affiliation wicri:level="3"><nlm:affiliation>Great Ormond Street Children's Hospital, Division of Blood and Marrow Transplantation, London, UK; Molecular Immunology Unit; UCL Institute of Child Health, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Great Ormond Street Children's Hospital, Division of Blood and Marrow Transplantation, London, UK; Molecular Immunology Unit; UCL Institute of Child Health, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Haddad, Elie" sort="Haddad, Elie" uniqKey="Haddad E" first="Elie" last="Haddad">Elie Haddad</name><affiliation wicri:level="1"><nlm:affiliation>Centre de Recherche du CHU Sainte-Justine, Département de Pédiatrie, Université de Montréal, Montréal, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre de Recherche du CHU Sainte-Justine, Département de Pédiatrie, Université de Montréal, Montréal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Albert, Michael H" sort="Albert, Michael H" uniqKey="Albert M" first="Michael H" last="Albert">Michael H. Albert</name><affiliation wicri:level="3"><nlm:affiliation>Dr von Hauner University Children's Hospital, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Dr von Hauner University Children's Hospital, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Hassan, Moustapha" sort="Hassan, Moustapha" uniqKey="Hassan M" first="Moustapha" last="Hassan">Moustapha Hassan</name><affiliation wicri:level="3"><nlm:affiliation>Division of Experimental Cancer Medicine, KFC, Novum, Laboratory Medicine, Karolinska University Hospital-Huddinge Stockholm, Sweden; Karolinska Institute, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Experimental Cancer Medicine, KFC, Novum, Laboratory Medicine, Karolinska University Hospital-Huddinge Stockholm, Sweden; Karolinska Institute, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author></analytic><series><title level="j">Lancet (London, England)</title><idno type="eISSN">1474-547X</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Antibodies, Monoclonal, Humanized (administration & dosage)</term><term>Antilymphocyte Serum (administration & dosage)</term><term>Busulfan (administration & dosage)</term><term>Child</term><term>Child, Preschool</term><term>Drug Therapy, Combination</term><term>Graft Survival (drug effects)</term><term>Graft vs Host Disease (prevention & control)</term><term>Granulomatous Disease, Chronic (therapy)</term><term>HLA Antigens</term><term>Hematopoietic Stem Cell Transplantation (methods)</term><term>Humans</term><term>Immunosuppressive Agents (administration & dosage)</term><term>Infant</term><term>Prospective Studies</term><term>Transplantation Chimera (physiology)</term><term>Transplantation Conditioning (methods)</term><term>Treatment Outcome</term><term>Vidarabine (administration & dosage)</term><term>Vidarabine (analogs & derivatives)</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Anticorps monoclonaux humanisés (administration et posologie)</term><term>Antigènes HLA</term><term>Association de médicaments</term><term>Busulfan (administration et posologie)</term><term>Chimère obtenue par transplantation (physiologie)</term><term>Conditionnement pour greffe ()</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Granulomatose septique chronique ()</term><term>Humains</term><term>Immunosuppresseurs (administration et posologie)</term><term>Jeune adulte</term><term>Maladie du greffon contre l'hôte ()</term><term>Nourrisson</term><term>Résultat thérapeutique</term><term>Survie du greffon ()</term><term>Sérum antilymphocyte (administration et posologie)</term><term>Transplantation de cellules souches hématopoïétiques ()</term><term>Vidarabine (administration et posologie)</term><term>Vidarabine (analogues et dérivés)</term><term>Études prospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antibodies, Monoclonal, Humanized</term><term>Antilymphocyte Serum</term><term>Busulfan</term><term>Immunosuppressive Agents</term><term>Vidarabine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Vidarabine</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Anticorps monoclonaux humanisés</term><term>Busulfan</term><term>Immunosuppresseurs</term><term>Sérum antilymphocyte</term><term>Vidarabine</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Vidarabine</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Graft Survival</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Hematopoietic Stem Cell Transplantation</term><term>Transplantation Conditioning</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Chimère obtenue par transplantation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Transplantation Chimera</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Graft vs Host Disease</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Granulomatous Disease, Chronic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Child</term><term>Child, Preschool</term><term>Drug Therapy, Combination</term><term>HLA Antigens</term><term>Humans</term><term>Infant</term><term>Prospective Studies</term><term>Treatment Outcome</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Antigènes HLA</term><term>Association de médicaments</term><term>Conditionnement pour greffe</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Granulomatose septique chronique</term><term>Humains</term><term>Jeune adulte</term><term>Maladie du greffon contre l'hôte</term><term>Nourrisson</term><term>Résultat thérapeutique</term><term>Survie du greffon</term><term>Transplantation de cellules souches hématopoïétiques</term><term>Études prospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In chronic granulomatous disease allogeneic haemopoietic stem-cell transplantation (HSCT) in adolescents and young adults and patients with high-risk disease is complicated by graft-failure, graft-versus-host disease (GVHD), and transplant-related mortality. We examined the effect of a reduced-intensity conditioning regimen designed to enhance myeloid engraftment and reduce organ toxicity in these patients.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Brésil</li><li>Canada</li><li>France</li><li>Israël</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suisse</li><li>Suède</li></country><region><li>Angleterre</li><li>Bavière</li><li>Canton de Zurich</li><li>District de Basse-Franconie</li><li>District de Haute-Bavière</li><li>Grand Londres</li><li>Hollande-Méridionale</li><li>Svealand</li><li>État de São Paulo</li><li>Île-de-France</li></region><settlement><li>Leyde</li><li>Londres</li><li>Munich</li><li>Paris</li><li>Stockholm</li><li>São Paulo</li><li>Wurtzbourg</li><li>Zurich</li></settlement><orgName><li>Université Paris-Descartes</li><li>Université de São Paulo</li></orgName></list><tree><country name="Suisse"><noRegion><name sortKey="Gungor, Tayfun" sort="Gungor, Tayfun" uniqKey="Gungor T" first="Tayfun" last="Güngör">Tayfun Güngör</name></noRegion><name sortKey="Schanz, Urs" sort="Schanz, Urs" uniqKey="Schanz U" first="Urs" last="Schanz">Urs Schanz</name><name sortKey="Seger, Reinhard" sort="Seger, Reinhard" uniqKey="Seger R" first="Reinhard" last="Seger">Reinhard Seger</name><name sortKey="Stussi, Georg" sort="Stussi, Georg" uniqKey="Stussi G" first="Georg" last="Stussi">Georg Stussi</name></country><country name="Canada"><noRegion><name sortKey="Teira, Pierre" sort="Teira, Pierre" uniqKey="Teira P" first="Pierre" last="Teira">Pierre Teira</name></noRegion><name sortKey="Ahmad, Imran" sort="Ahmad, Imran" uniqKey="Ahmad I" first="Imran" last="Ahmad">Imran Ahmad</name><name sortKey="Haddad, Elie" sort="Haddad, Elie" uniqKey="Haddad E" first="Elie" last="Haddad">Elie Haddad</name><name sortKey="Lachance, Silvy" sort="Lachance, Silvy" uniqKey="Lachance S" first="Silvy" last="Lachance">Silvy Lachance</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Slatter, Mary" sort="Slatter, Mary" uniqKey="Slatter M" first="Mary" last="Slatter">Mary Slatter</name></noRegion><name sortKey="Gaspar, H Bobby" sort="Gaspar, H Bobby" uniqKey="Gaspar H" first="H Bobby" last="Gaspar">H Bobby Gaspar</name><name sortKey="Gennery, Andrew" sort="Gennery, Andrew" uniqKey="Gennery A" first="Andrew" last="Gennery">Andrew Gennery</name><name sortKey="Hough, Rachel" sort="Hough, Rachel" uniqKey="Hough R" first="Rachel" last="Hough">Rachel Hough</name><name sortKey="Veys, Paul" sort="Veys, Paul" uniqKey="Veys P" first="Paul" last="Veys">Paul Veys</name></country><country name="Israël"><noRegion><name sortKey="Stepensky, Polina" sort="Stepensky, Polina" uniqKey="Stepensky P" first="Polina" last="Stepensky">Polina Stepensky</name></noRegion><name sortKey="Resnick, Igor B" sort="Resnick, Igor B" uniqKey="Resnick I" first="Igor B" last="Resnick">Igor B. Resnick</name></country><country name="France"><region name="Île-de-France"><name sortKey="Moshous, Despina" sort="Moshous, Despina" uniqKey="Moshous D" first="Despina" last="Moshous">Despina Moshous</name></region><name sortKey="Fischer, Alain" sort="Fischer, Alain" uniqKey="Fischer A" first="Alain" last="Fischer">Alain Fischer</name></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Vermont, Clementien" sort="Vermont, Clementien" uniqKey="Vermont C" first="Clementien" last="Vermont">Clementien Vermont</name></region><name sortKey="Bredius, Robbert" sort="Bredius, Robbert" uniqKey="Bredius R" first="Robbert" last="Bredius">Robbert Bredius</name></country><country name="Australie"><noRegion><name sortKey="Shaw, Peter J" sort="Shaw, Peter J" uniqKey="Shaw P" first="Peter J" last="Shaw">Peter J. Shaw</name></noRegion></country><country name="Brésil"><region name="État de São Paulo"><name sortKey="Telles Da Cunha, Jose Marcos" sort="Telles Da Cunha, Jose Marcos" uniqKey="Telles Da Cunha J" first="José Marcos" last="Telles Da Cunha">José Marcos Telles Da Cunha</name></region><name sortKey="Fernandes, Juliana F" sort="Fernandes, Juliana F" uniqKey="Fernandes J" first="Juliana F" last="Fernandes">Juliana F. Fernandes</name></country><country name="Allemagne"><region name="Bavière"><name sortKey="Schlegel, Paul G" sort="Schlegel, Paul G" uniqKey="Schlegel P" first="Paul G" last="Schlegel">Paul G. Schlegel</name></region><name sortKey="Albert, Michael H" sort="Albert, Michael H" uniqKey="Albert M" first="Michael H" last="Albert">Michael H. Albert</name><name sortKey="Belohradsky, Bernd H" sort="Belohradsky, Bernd H" uniqKey="Belohradsky B" first="Bernd H" last="Belohradsky">Bernd H. Belohradsky</name><name sortKey="Gruhn, Bernd" sort="Gruhn, Bernd" uniqKey="Gruhn B" first="Bernd" last="Gruhn">Bernd Gruhn</name><name sortKey="Kentouche, Karim" sort="Kentouche, Karim" uniqKey="Kentouche K" first="Karim" last="Kentouche">Karim Kentouche</name></country><country name="Suède"><noRegion><name sortKey="Fasth, Anders" sort="Fasth, Anders" uniqKey="Fasth A" first="Anders" last="Fasth">Anders Fasth</name></noRegion><name sortKey="Hassan, Moustapha" sort="Hassan, Moustapha" uniqKey="Hassan M" first="Moustapha" last="Hassan">Moustapha Hassan</name><name sortKey="Rentsch, Katharina" sort="Rentsch, Katharina" uniqKey="Rentsch K" first="Katharina" last="Rentsch">Katharina Rentsch</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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